Pdf investigation of pharmacognostical and preliminary. Effect of aqueous enicostemma littorale blume extract on key. Acute and subchronic toxicity studies of swertiamarin a lead compound isolated from enicostemma littorale blume in wistar rats 3331 downloads chemical composition and antimicrobial effects of calendula officinalis grown under chemical and biological conditions on the methicillinresistant staphylococcus aureus isolated from hospital. Several studies have reported the hypoglycaemic properties of ginger. The purpose of this study is to investigate the efficacy and safety of mamajjaka ghanavati on blood glucose level, symptoms, and quality of life in patients with type 2. A new therapeutic target for islet neogenesis extract preparation and isolation of sgl1 plant material was dried and cut into small pieces. Enicostemma axillare is a perennial herb belonging to family gentianaceae and is cosmopolitan in occurrence in india. The antidiabetic activity of enicostemma littorale mamajjaka leaf extracts was investigated in streptozotocininduced diabetic albino rats.
In india, the plant is traditionally used in the treatment of rheumatism abdominal ulcers, hernia, swelling and insect poisoning 19. Pdf medicinal plants are playing a significant role in curing various diseases from ancient times. The anti inflammatory activity of enicostemma littorale e. Antinociceptive activity of swertiamarin isolated from. Enicostemma littorale blume a potential hypolipidemic plant natural product radiance vol 36 novemberdecember 2004 keywords. Acute and subchronic toxicity studies of swertiamarin a lead compound isolated from enicostemma littorale blume in wistar rats 3331 downloads chemical composition and antimicrobial effects of. Estimation of various biochemical parameters showed. Written from a farmtofork perspective, food safety. Haghi, ana cristina faria ribeiro, lionello pogliani, devrim balkose, francisco torrens, omari v.
Indian journal of experimental biology, 38, 781784. Littorale shadedried herb 1 kg contaning all vegitative and reproductive parts of e. Conclusion the terpenoids were believed to contribute to various medicinal properties. Theory and practice provides a comprehensive overview of food safety and discusses the biological, chemical, and physical agents of foodborne diseases. Investigatory study of long term doses of costus afer, snail. Restoration ofliver function bythe application of enicostemma littorale. Their use in folk medicine and phytomedicine is in the treatment and management of variety of. Download applied chemistry and chemical engineering, volume 5. The plant acts as a laxative, helps in curing fever, obesity, rheumatism, snake bite, skin disease, abdominal disorders and regulate blood sugar levels. Many chemical and biochemical compounds make stem cells to get differentiate into insulin. Dose dependent hypoglycemic effect of aqueous extract of. The present study investigates the effect of oral administration of an aqueous enicostemma littorale whole plant extract on some key carbohydrate metabolic enzymes and antioxidant defence in alloxan. A small molecule swertisin from enicostemma littorale differentiates nih3t3 cells into isletlike clusters and restores normoglycemia upon transplantation in diabetic balbc mice nidheesh dadheech, 1 sanket soni, 1 abhay srivastava, 1 sucheta dadheech, 1 shivika gupta, 2 renjitha gopurappilly, 3 ramesh r. Bioinformatics analysis of differentially expressed genes.
In the present study in vivo antinociceptive activity of swertiamarin isolated from e. Enicostemma littorale, chhotachirayta, p dimethylaminoazobenzene pdab, hepatotoxicity, lipid profile, lipid peroxidation, yglutamyl transpeptidase. Haghi, ana cristina faria ribeiro, lionello pogliani, devrim. Many traditional indian medicinal plants which contain large quantity of a secoiridoid, swertiamarin are being used to relieve pain. Hypoglycemic herbs and their action mechanisms chinese.
Rapid regeneration of enicostemma littorale blume from leaf and stem cultures. Ageratum littorale, cape sable whiteweed is a plant species native to florida, the common name referring to cape sable inside everglades national park. Pdf phytochemical and pharmacognostic value of enicostemma. Mamajjaka international journal of biopharmaceutics. Flora of north america consider this as being the same species as the west indian a. Antihyperglycemic and antihyperlipidemic effects of aqueous. A high frequency and rapid regeneration protocol was developed from leaf and nodal explants of enicostemma littorale blume on ms medium supplemented. Evaluation of effect of aqueous extract of enicostemma littorale. Some structures of chemical constituents from enicostemma littorale are presented in table 2.
Green synthesis and characterization of silver nanoparticles. Enicostemma littorale blume belonging to family gentianaceae. Enicostema littorale is an herb found in many parts of india. Chloroform, methanol and acetone extracts of different parts of e. Pdf downloads biosciences biotechnology research asia. Chapter 3 antifungal activity of few medicinal plants. The concentration of swertiamarin in the alcoholic extract of dried powder of enicostema littorale by the proposed hptlc method. Phytochemical screening, antihyperglycemic and antihyperlipidemic effects of aqueous extracts of l. Enicostemma littorale blume, the folk medicineis used for rheumatic pain and it was selected for scientific validation. Enicostemma littorale blume, the folk medicine is used for rheumatic pain and it was selected for scientific validation. Pharmaceutical development and evaluation of mamajjaka ghanavati. Analgesic and antiarthritic effect of enicostemma littorale.
Enicostemma littorale blume a potential hypolipidemic plant nopr. Blume aerial part powder in pdab pdimethylaminoazobenzene induced animals was. Enicostemma littorale protect to ros cause islets of langerhans to apoptosis 14. The 85% methanolic extract obtained from the whole plant of enicostemma.
Research methodologies in modern chemistry and applied science by a. Enicostemma littorale is a medicinal plant belongs to family gentianaceae, found throughout india common in coastal areas. The analgesic activity has been evaluated by hot plate and tail immersion. An effective method for isolation of pure swertiamarin.
Theory and practice in hospitality and tourism research includes 111 contributions from the 2nd international hospitality and tourism conference 2014 penang, malaysia, 24 september 2014, and covers a comprehensive. Pdf antidiabetic activity of enicostemma littorale mamajjaka. Antiulcer and antiinflammatory activity of aerial parts enicostemma littorale blume. The role of free entry, sajal lahiri and yoshiyasu ono. It is a 25 inches tall herb, growing throughout india.
The labgenerated data was compared with reported data and found that this method is the best method for the isolation of pure swertiamarin in quality as well as quantity. Food safety theory and practice download ebook pdf, epub. Antioxidant activity of enicostemma axillare in vitro studies. Pdf applied chemistry and chemical engineering, volume 5.
It has a role as an antibacterial agent, an antioxidant, a protein kinase inhibitor, an antineoplastic agent, an ec 1. Information from its description page there is shown below. Antihyperglycemic and antihyperlipidemic effects of. Pdf rapid regeneration of enicostemma littorale blume. In the present study, we have investigated the effect of aqueous extract of e. A small molecule swertisin from enicostemma littorale differentiates nih3t3 cells into isletlike clusters and restores normoglycemia upon transplantation in diabetic balbc mice nidheesh. Previously, we have reported that aqueous extract of enicostemma littorale has potential antidiabetic activity. It is cited in ancient literature as an antimalarial, antipyretic and as a laxative 9. Enicostemma littoraleblume is a glabrous perennial herb belonging to the family gentianaceae.
Current science is a fortnightly journal published since 1932 by the current science association, bangalore india in collaboration with the indian academy of sciences. Conclusion the terpenoids were believed to contribute to. For the synthesis of silver nanoparticles, 2 ml of the aqueous extract of enicostemma axillare add into erlenmeyer flask containing 60 ml of 1 mm silver nitrate agno 3 sigmaaldrich, st. Diabetes, enicostemma littorale, iddm, stz, swertiamarin. We report herein the findings of this research work. Quercetin is a pentahydroxyflavone having the five hydroxy groups placed at the 3, 3, 4, 5 and 7positions. Estimation of various biochemical parameters showed that e. Hence the confirmation on presence of terpenoids and its antimicrobial activity shall drive the research towards determining the cytotoxic effects of the e.
Biosynthesis of copper oxide nanoparticles using enicostemma. Text is available under the creative commons attributionsharealike license. Doe analysis of variance design of experiments free. Investigatory study of long term doses of costus afer. Many chemical and biochemical compounds make stem cells to get differentiate into insulin producing cells. The study resulted that antifungal activity of test plants showed significant activity with. In diabetes mellitus antihyperglycaemic effect of several plants, extracts and herbal. Ebook food safety theory and practice as pdf download. The study resulted that antifungal activity of test plants showed significant activity with methanol extract followed by ethanol extract, whereas aqueous extract of tested plants did not show any antifungal activity. Enicostemma littorale pills prepared from enicostemma littorale gentianaceae were administered to 84 patients with type 2 diabetes for three months.
Scientific monograph, amrit pal singh pdf emission standard versus tax under oligopoly. Doe analysis of variance design of experiments free 30. Lam raynal synonym enicostemma littorale blume, gentianaceae is a perennial. Enicostemma littorale is one of the traditional drugs used mainly in gujarat, madhya pradesh, and rajasthan as a stomachic, tonic, carminative and appetizer. Evaluation of effect of aqueous extract of enicostemma. Chemical constituents present in enicostemma littorale sr.
Rapid regeneration of enicostemma littorale blume from leaf and. Pharmaceutical development and evaluation of mamajjaka. The 85% methanolic extract obtained from the whole plant of enicostemma littorale has been assessed for analgesic and antiinflammatory activity. The study demonstrates the utility of this developed method to isolate pure swertiamarin form enicostemma littorale in a fast and effective manner. Enicostemma littorale blume a potential hypolipidemic plant. Efficacy and safety of mamajjaka ghanavati in the treatment. Multipotent differentiation property of stem cells opens up new arena for the treatment of diabetic patients. Phytochemical and pharmacognostic value of enicostemma littorale.
Zingiber officinale zo, commonly known as ginger, has been traditionally used in the treatment of diabetes mellitus. An active herbal compound sgl1 was isolated and purified from extract of. To study detailed pharmacognostic profile and preliminary phytochemical investigation of whole plant of enicostemma littorale gentianaceae is a perennial herb found throughout india. Iridoids present in a wide variety of medicinal plants possess a large number of medicinal properties. Effect of aqueous enicostemma littorale blume extract on. Bioinformatics analysis of differentially expressed genes in. Return articles published in year or between years return articles published in year or between years. We report a simple method for the isolation of swertiamarin, a secoiridoid glycoside, from the whole plant of enicostemma littorale blume.
Enicostemma littorale extract have been proven its antimalarial activity while investigated for invitro and in vivo antiplasmodial activities. The plant acts as a laxative, helps in curing fever, obesity, rheumatism, snake bite. Comparative phytophysicochemical studies on selected medicinal plants, enicostemma littorale blume and withania somnifera dunal vinotha sanmugarajah1, ira thabrew2, sri ranjani sivapalan1 1unit of siddha medicine, university of jaffna, sri lanka. This page was last edited on 14 december 2019, at 23. Dose dependent hypoglycemic effect of aqueous extract of enicostemma littorale blume in alloxan induced diabetic rats. Effect of aqueous enicostemma littorale blume extract on key carbohydrate metabolic enzymes, lipid peroxides and antioxidants in alloxaninduced diabetic rats. No name structure reference 1 apigenin o oh o ho h oh h ghosal et al 1974 2 swertisin chaudhuri rk, singh ak, ghosal s et al 1975. Enicostema littorale is an herb from the plant family gentianaceae. Stem cylindric, glabrous with a decurrent ridge below each leaf. An active herbal compound sgl1 was isolated and purified from extract of enicostemma littorale and used to differentiate two model stem cell lines panc1 and nih3t3 which showed tremendous islet neogenic potential and significant islet yield. The present investigation was undertaken to standardize and study the dosedependent effect of three weeks treatment with hot and cold aqueous extract of e. A small molecule swertisin from enicostemma littorale. The overall result showed that aqueous extract of enicostemma littorale blume mamajjaka exhibit excellent potential to minimize the oxidative stress in metabolic. A rapid method for the isolation of swertiamarin from enicostemma.
The bittery natured plant acts as a laxative, helps in curing fever, rheumatism, skin diseases, abdominal disorders, snake bite, obesity and helps to regulate blood sugar levels. Antiulcer and antiinflammatory activity of aerial parts enicostemma. Iridoids present in a wide variety of medicinal plants. Drug consists of dried whole plant mostly root and vegetative parts of enicostemma hyssopifolium willd. This herb is also found in south america and some parts of africa. It is generally prescribed in the form of vati for the treatment of type 2 diabetes in ayurveda. Hence the confirmation on presence of terpenoids and its antimicrobial activity shall drive the research towards. Conventional drugs treat diabetes by improving insulin sensitivity, increasing insulin production andor decreasing the amount of glucose in blood. Theory and practice provides a comprehensive overview of food safety and discusses the biological. It is one of the most abundant flavonoids in edible vegetables, fruit and wine. The shoots of plant enicostemma littorale blume were collected from karnataka india from august to september, 2005 at the end of flowering. Phytochemical and pharmacognostic value of enicostemma. Present study highlighted islet neogenic property of one herbal plant enicostemma littorale blume. Amelioration of stzinduced type 1 diabetic nephropathy by aqueous extract of enicostemma littorale blume and swertiamarin in rats.
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